Tracy Grandstaff

as Daria Morgendorffer (voice)

Wendy Hoopes

as Jane Lane / Quinn Morgendorffer / Helen Morgendorffer (voice)

Julián Rebolledo

as Jake Morgendorffer (voice)

Marc Thompson

as Kevin Thompson (voice)

Alvaro J. Gonzalez

as Trent Lane (voice)

Jessica Cydnee Jackson

as Jodie Landon (voice)

Janie Mertz

as Brittany Taylor / Sandi Griffin (voice)

Geoffrey Arend

as Charles "Upchuck" Ruttheimer III (voice)